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	孫 建 安
	教授 (學程主任)

學歷	美國約翰霍普金斯大學公共衛生學院博士
研究專長	流病病學、公共衛生、資料分析
服務電話	02-2905-3432
Email	040866@mail.fju.edu.tw

期刊論文

NCD Risk Factor Collaboration (NCD-RisC)，「Rising rural body mass index is the main driver of the global obesity epidemic in adults」，Nature 卷， 期 (2019-05-09) ：260-264 (SCI) NCD Risk Factor Collaboration (NCD-RisC)，「Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants」，International Journal of Epidemiology 卷， 期 (2018-06-01) ：872-883 (SCI) Wen-Chih Wu、Po-Chien Hsieh、Fu-Kang Hu、Jen-Chun Kuan、Chi-Ming Chu、Chien-An Sun、Tsan Yang、Sui-Lung Su、Yu-Ching Chou，「Long-term predictive models of risk factors for early chronic kidney disease:a longitudinal study」，Oncotarget 卷， 期 (2018-04-13) ：19745-19752 (SCI) Je-Ming Hu、Cheng-Jung Shen、Yu-Ching Chou、Chi-Feng Hung、Yu-Feng Tian、San-Lin You、Chao-Yang Chen、Chih-Hsiung Hsu、Cheng-Wen Hsiao、Chun-Yu Lin、Chien-An Sun，「Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study」，International Journal of Colorectal Disease 卷， 期 (2018-03-01) ：349-352 (SCI) NCD Risk Factor Collaboration，「Worldwide trend in body mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults」，Lancet 卷， 期 (2017-12-16) ：2627-2642 (SCI) Yen-Chun Fen、Chia-Chi Chou、San-Lin You、Chien-An Sun、Chien-Jen Chen、Chyi-Huey Bai，「Impact of worsened metabolic syndrome on the risk of dementia:A nationwide cohort study」，Journal of American Heart Association 卷， (2017-09-12) ：1-9 (SCI) Chien-Hua Chen、Chien-An Sun、Yu-Ching Chou、Chao-Hsien Lee、Szu-Mei Hsiao、Tsan Yang，「A study on the correlation between gallbladder polyps and metabolic syndrome combined with fatty liver disease: an analysis of physical examination data」，International Journal of Medical and Health Research 卷， 期 (2017-05-01) ：20-25 (其他) NCD Risk Factor Collaboration (NCD-RisC)，「Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants」，Lancet 卷， 期 (2017-01-07) ：37-55 (SCI) Hsien-Feng Chang、Chang-Chieh Wu、Chien-An Sun、Chi-Ming Chu、Fu-Gong Lin、Jih-Fu Hsieh、Chih-Hsiung Hsu、Tsan Yang、Yang-Ming Tsai、Jen-Chun Kuan、Yu-Ching Chou，「Clinical stage and risk of recurrence and mortality: interaction of DNA methylation factors in patients with colorectal cancer」，Journal of Investigative Medicine 卷， 期 (2016-10-01) ：1200-1207 (SCI) NCD Risk Factor Collaboration (NCD-RisC)，「A centuary of trends in adult human height」，eLIfe 卷， (2016-08-01) ：1-29 (SCI) Feng-Chi Hsueh、Chih-Mei Chen、Chien-An Sun、Yu-Ching Chou、Szu-Mei Hsiao、Tsan Yang，「A study on the effects of a health education intervention on anxiety and pain during colonoscopy procedures」，Journal of Nursing Research 卷， 期 (2016-06-01) ：181-189 (SCI) Lin SC、Sun CA、You SL、Hwang LC、Liang CY、Yang T、Bai CH、Chen CH、Wei CY、Chou YC，「The Link of Self-Reported Insomnia Symptoms and Sleep Duration with Metabolic Syndrome: A Chinese Population-Based Study」，Sleep 卷， 期 (2016-06-01) ：1261-1266 (SCI) Shih-Chieh Lin、Chien-An Sun、San-Lin You、Lee-Ching Hwang、Chun-Yu Liang、Tsan Yang、Chyi-Huey Bai、Chien-Hua Chen、Cheng-Yu Wei、Yu-Ching Chou，「The Link of Self-Reported Insomnia Symptoms and Sleep Duration with Metabolic Syndrome: A Chinese Population-Based Study」，Sleep 卷， 期 (2016-06-01) ：1261-6 (SCI) En-Chi Shih、Wen-Li Hou、Pi-Li Lin、Szu-Mei Hsiao、Chien-An Sun、Yu-Ching Chou、Tsan Yang，「Personal characteristics, workplace stressors, and occupational burnout among psychiatric nurses in southern Taiwan: A cross-sectional study」，Nursing and Health 卷， 期 (2016-06-01) ：15-23 (其他) NCD Risk Factor Collaboration (NCD-RisC)，「Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants」，Lancet 卷， 期 (2016-04-09) ：1513-1530 (SCI) NCD Risk Factor Collaboration (NCD-RisC)，「Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants」，Lancet 卷， (2016-04-02) ：1377-1396 (SCI) Shih-Chun Hsing、Kuo-Cheng Lu、Chien-An Sun、Wu-Chien Chien、Chi-Hsiang Chung、Sen-Yeong Kuo，「The Association of Losartan and Ramipril Therapy With Kidney and Cardiovascular Outcomes in Patients With Chronic Kidney Disease: A Chinese Nation-Wide Cohort Study in Taiwan」，Medicine 卷， 期 (2015-12-07) ：e1999 (SCI) Chi-Ling Chen、Jyh-Yuan Yang、Szu-Fong Lin、Chien-An Sun、Chyi-Huey Bai、San-Lin You、Chien-Jen Chen、Jia-Horng Kao、Pei-Jer Chen、Ding-Shinn Chen，「Slow decline of hepatitis B burden in general population: Results from a population-based survey and longitudinal follow-up study in Taiwan」，Journal of Hepatology 卷， 期 (2015-08-01) ：354-363 (SCI) Yu-Ching Chou、Jen-Chun Kuan、Tsan Yang、Wan-Yun Chou、Po-Chien Hsieh、Chyi-Huey Bai、San-Lin You、Chien-Hua Chen、Cheng-Yu Wei、Chien-An Sun，「Elevated uric acid level as a significant predictor of chronic kidney disease: A cohort study with repeated measurements」，Journal of Nephrology 卷， 期 (2015-08-01) ：457-462 (SCI) Cheng-Yu Wei、Chia-Cheng Sun、James Cheng-Chung Wei、Hsu-Chih Tai、Chien-An Sun、Chian-Fang Chung、Yu-Ching Chou、Pi-Li Lin、Tsan Yang，「Association between hyperuricemia and metabolic syndrome: An epidemiological study of a labor force population in Taiwan」，Biomed Research International 卷， (2015-07-27) ：1-7 (SCI) Yu-Ching Chou、Jen-Chun Kuan、Chyi-Huey Bai、Tsan Yang、Wan-Yun Chou、Po-Chien Hsieh、San-Lin You、Lee-Ching Hwang、Chien-Hua Chen、Cheng-Yu Wei、Chien-An Sun，「Predictive value of serum apolipoprotein B/apoliprotein A-I ratio in metabolic syndrome: a Chinese cohort study」，Endocrine 卷， 期 (2015-06-01) ：404-414 (SCI) Jen-Chun Kuan、Chang-Chieh Wu、Chien-An Sun、Chi-Ming Chu、Fu-Gong Lin、Chih-Hsiung Hsu、Po-Chieh Kan、Shih-Chieh Lin、Tsan Yang、Yu-Ching Chou，「DNA methylation combinations in adjacent normal colon tissue predict cancer recurrence: Evidence from a clinical cohort study」，PLos One 卷， 期 (2015-03-01) ：e0123396 (SCI) Tsan Yang、Chien-An Sun、Yu-Ching Chou、Chia-Hsin Lai、Chun-Chieh Chao、Chao-Hsien Lee、Chi Chang、Ling-Mei Yang，「Gender differences in obesity indices in a 10-year risk for cardiovascular disease」，British Journal of Medicine & Medical Research 卷， 期 (2015-01-01) ：1121-1130 (其他) Yong-Chen Chen、Chien-An Sun、Tsan Yang、Chi-Hong Chou、Chyi-Huey Bai、San-Lin You、Lee-Ching Hwang、Chien-Hua Chen、Cheng-Yu Wei、Yu-Ching Chou，「Impact of metabolic syndrome components on incident stroke subtypes: A Chinese cohort study」，Journal of Human Hypertension 卷， 期 (2014-11-01) ：689-693 (SCI) Chien-Hua Chen、Mei-Chia Chen、Szu-Mei Hsiao、P、Chien-An Sun、Yu-Ching Chou、Tsan Yang，「Evaluating the effects of the components of metabolic syndrome, fatty liver and liver function on chronic hepatitis C: Data analysis of adult health eaminations」，World Journal of Medicine and Medical Science 卷， 期 (2014-11-01) ：1-11 (其他) Tsan Yang、Yu-Ching Chou、Chi-Hong Chu、Shih-Hua Lin、Po-Chien Hsieh、Chih-Hsung Hsu、Chyi-Huey Bai、San-Lin You、Chien-An Sun，「Metabolic syndrome and Creactive protein concentration as independent correlates of chronic kidney disease」，Endocrine Research 卷， 期 (2014-06-01) ：94-98 (SCI) Feng-Chi Hsueh、Han-Chih Wang、Chien-An Sun、Chia-Chen Tseng、Tung-Hua Chen、Szu-Mei Hsiao、Cheng-Yu Wei、Chien-Hua Chen、Tsan Yang，「The effect of different patient education methods on qquality of bowel cleanliness in outpatients receiving colonoscopy examination」，Applied Nursing Research 卷， 期 (2014-05-01) ：e1-e5 (SCI) Ling-Mei Yang、Chien-An Sun、Yu-Ching Chou、Xiu-Mei Wang、Szu-Mei Hsiao、Pi-Li Lin、Wen-Li Hou、Tsang Yang，「Care interventions on the health indicators of patients with early-stage chronic kidney disease」，Journal of Applied Medical Sciences 卷， 期 (2014-03-01) ：47-60 (其他) Mei-Chin Chen、Ying-Wei Huang、Chien-An Sun、Chao-Hsien Lee、Szu-Mei Hsiao、Yu-Ching Chou、Tung-Chen Han、Tsan Yang，「Factors influencing the quality of life of nurse anesthetists and the correlations among ork stress, job satisfaction, and quality of life: A case study of three medical centers in southern Taiwan」，World Journal of Medicine and Medical Science 卷， 期 (2014-02-01) ：1-17 (其他) MeiChin Chen、Ying-ei Huang、Wen-Li Hou、Chien-An Sun、Yu-Ching Chou、Su-Feng Chu、Tsan Yang，「The correlations between work stress, job satisfaction and quality of life among nurse anesthetists working in medical centers in southern Taiwan」，Nursing and Health 卷， 期 (2014-02-01) ：35-47 (其他) Ya-Wen Chen、Sheng-Yuan Huang、Chao-Chin Chao、Chien-An Sun、Chien-Hua Chen、Cheng-Yu Wei、Yu-Ching Chou、Tsan Yang，「Association between uric acid level and chronic kidney disease in middle-aged and elderly subjects in southern Taiwan」，Journal of Applied Medical Sciences 卷， 期 (2013-09-01) ：9-23 (其他) Wen-Chih Wu、Chih-Hsiung Hsu、Jen-Chun Kuan、Jih-Fu Hsieh、Chien-An Sun、Tsan Yang、Chang-Chien Wu、Yu-Ching Chou，「Predicting the progress of colon cancer by DNA methylation markers of the p16 gene in feces: Evidence from an animal model」，Genetics & Molecular Biology 卷， 期 (2013-09-01) ：323-328 (SCI) Hsiu-Chen Chang Chie、Su-Feng Chu、Chi Chang、Chien-An Sun、Yu-Ching Chou、Su-Chun Hsueh、Tsan Yang，「The effects of personal background and occupational stress on the QOL of Vietnamese care attendants working at medical institutions in Taiwan」，American Journal of Nursing Science 卷， 期 (2013-08-01) ：40-49 (其他) Tsan Yang、Chien-An Sun，「Authors reply to Dr. Kawada’s comments」，Endocrine ， (2013-08-01) (SCI) En-Chi Shih、Hsin-Hui Chiu、Chien-An Sun、Cheng-Yu Wei、Yu-Ching Chou、Tsan Yang，「Impact of personal characteristics and work stress on job burnout among psychiatric nurses」，Innovative Journal of Medical and Health Sciences 卷， 期 (2013-07-01) ：201-208 (其他) Lee-Ching Hwang、Chyi-Huey Bai、San-Lin You、Chien-An Sun、Chien-Jen Chen，「Description and Prediction of the development of metabolic syndrome: A longitudinal analysis using a Markov model approach」，PLos One 卷， 期 (2013-06-01) ：e67436-ee67441 (SCI) Tsan Yang、Chi-Hong Chu、Po-Chien Hsieh、Chih-Hsung Hsu、Yu-Ching Chou、Shih-hsien Yang、Chyi-Huey Bai、San-Lin Ypou、Lee-Ching Hwang、Chien-An Sun，「C-reactive protein concentration as a significant correlate for metabolic syndrome: a Chinese population-based study」，Endocrine 卷， 期 (2013-04-01) ：351-359 (SCI) Chang-Chieh Wu、Jen-Chun Kuan、Chih-Hsiung Hsu、Tzu-An Chen、Chien-An Sun、Tsan Yang、Shinn-Long Lin、Yu-Ching Chou，「A study of the frequency of methylation of gene promoter regions in colorectal cancer in the Taiwanese population 」，Journal of Genetics 卷， 期 (2013-04-01) ：109-113 (SCI) Chuan-Hsin Chen、Wen-Chih Wu、Yu-Chin Chou、Chien-An Sun、Tsan Yang，「Exploring the relationships between metabolic syndrome, depression and sleep quality within hospital administrative staffs in a regional hospital in Southern Taiwan 」，Chinese Journal of Occupational Medicine 卷， 期 (2013-01-01) ：39-53 (其他) Tsan Yang、Chi-Hong Chu、Chyi-Huey Bai、San-Lin You、Yu-Ching Chou、Lee-Ching Hwang、Kuo-Liong Chien、Ta-Chen Su、Chin-Hsiao Tseng、Chien-An Sun，「Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study」，Metabolism 卷， 期 (2012-12-01) ：1747-1755 (SCI) Hsiu-Chen Chang Chen、Chao-Hsien Lee、Chien-An Sun、Yu-Ching Chou、Tsan Yang，「Factors influencing the quality of life of Vietnamese nursing aides working at medical institutions in Taiwan」，Journal of Nursing and Healthcare Research 卷， 期 (2012-09-01) ：212-222 (其他) Yang T、Chu CH、Hsu CH、Hsieh PC、Chung TC、Bai CH、You SL、Hwang LC、Lin CM、Sun CA，「Impact of metabolic syndrome on the incidence of chronic kidney disease; A Chinese cohort study」，Nephrology 卷， 期 (2012-08-01) ：532-538 (SCI) Lee MH、Yang HI、Lu SN、Jen CL、You SL、Wang LY、Wang CH、Chen WJ、Chen CJ、Hsieh CY、Lee HS、Yang PM、Chen CH、Chen JD、Huang SP、Jan CF、Chen THH、Sun CA、Wu MH、Chen SY、Chu KE、Ho SC、Lu TG、Wu WP、Ou TY、Lin CG、Shih KC、Chung WS、Li C、Chen CC、How WC，「Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases:A community-based long-term prospective study」，Journal of Infectious Diseases 卷， 期 (2012-08-01) ：469-477 (SCI) Tu SF、Chou YC、Sun CA、Hsueh SC、Yang T，「The prevalence of metabolic syndrome and factors associated with quality of dialysis among hemodialysis patients in southern Taiwan」，Global Journal of Health Science 卷， 期 (2012-07-01) ：53-62 (其他) Lee-Ching Hwang、Chyi-Huey Bai、Chien-An Sun、Chien-Jen Chen，「Prevalence of metabolically healthy obesity and its impacts on incidences of hypertension, diabetes and the metabolic syndrome in Taiwan」，Asia Pacific Journal of clinical Nutrition 卷， 期 (2012-04-01) ：227-233 (SCI) Tsan Yang、Chi-Hong Chu、Chyi-Huey Bai、San-Lin You、Yu-Ching Chou、Wan-Yun Chou、Kuo-Liong Chien、Lee-Ching Hwang、Ta-Chen Su、Chien-An Sun，「Uric acid level as a risk marker for metabolic syndrome: A Chinese cohort study」，Atherosclerosis 卷， 期 (2012-02-01) ：525-531 (SCI) Yang T、Sun CA、Chen CC、Wu SH、Chung TC、Chou YC，「The association between metabolic syndrome-related indicators and ten-year risk of cardiovascular disease: An epidemiologic assessment」，ISRN Public Health ， (2012-02-01) ：1-7 (其他) Yu-Ching Chou、Chi-Hong Chu、Mei-Hsuan Wu、Giu-Cheng Hsu、Tsan Yang、Wan-Yun Chou、Meei-Shyuan Lee、Cheng-Ping Yu、Jyh-Cherng Yu、Chien-An Sun，「Dietary intake of vitamin B6 and risk of breast cancer in Taiwanese women」，Journal of Epidemiology 卷， 期 (2011-09-01) ：329-336 (SCI) Mei-Hsuan Wu、Chi-Hong Chu、Yu-Ching Chou、Tsan Yang、Giu-Cheng Hsu、Cheng-Ping Yu、Jyh-Cherng Yu、 孫建安 ，「Joint effect of peroxisome proliferator-activated receptor gamma genetic polymorphisms and estrogen-related risk factors on breast cancer risk: results from a case-control study in Taiwan 」，Breast Cancer Research and Treatment 卷， 期 (2011-06-01) ：777-784 (SCI) Mei-Hsuan Lee、Hwai-I Yang、Chin-Lan Jen、Sheng-Nan Lu、Shiou-Hwei Yeh、Chun-Jen Liu、San-Lin You、Chien-An Sun、Li-Yu Wang、Wei J Chen，「Community and personal risk factors for hepatitis C virus infection: a survey of 23820 residents in Taiwan in 1991-2」，Gut 卷， 期 (2011-04-01) ：688-694 (SCI) Meei-Shyuan Lee、Yi-Chen Huang、Mark L Wahlqvist、Tsai-Yi Wu、Yu-Ching Chou、Mei-Hsuan Wu、Jyh-Cherng Yu、Chien-An Sun，「Vitamin D Decreases Risk of Breast Cancer in Premenopausal Women of Normal Weight in Subtropical Taiwan」，Journal of Epidemiology 卷， 期 (2011-02-01) ：87-94 (SCI) Sun CA、Wu MH、Chu CH、Chou YC、Hsu GC、Yang T、Chou WY、Yu CP、Yu JC，「Adipocytokine resistin and breast cancer risk」，Breast Cancer Res Treat 卷， 期 (2010-10-01) ：869-876 (SCI) Jin-De Chen、Hwai-I Yang、Uchenna H. Iloeje、San-Lin You、Sheng-Nan Lu、Li-Yu Wang、Jun Su、Chien-An Sun、Yun-Fan Liaw、Chien-Jen Chen，「Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death」，Gastroenterology 卷， 期 (2010-05-01) ：1747-1754 (SCI) Wu MH 、Chou YC 、Chou WY、Hsu GC 、Chu CH 、Yu CP 、Yu JC、Sun CA ，「Relationships between critical period of estrogen exposure and circulating levels of insulin-like growth factor-I (IGF-І) in breast cancer: Evidence from a case-control study」，International Journal of Cancer 卷， 期 (2010-01-01) ：508-514 (SCI) 林芳子、黃致錕、李昭憲、孫建安、楊燦，「A preliminary study on the effects of health related indicators from community exercise-walking intervention for the middle-aged and elderly」，台灣健康照顧研究學刊 ， 期 (2010-01-01) ：55-70 Wu MH、Chou YC、Chou WY、Hsu GC、Chu CH、Yu CP、Yu JC、Sun CA，「Circulating levels of leptin, adiposity and breast cancer risk.」，Br J Cancer 卷， 期 (2009-02-01) ：578-582 (SCI) Wu MH、Chou YC、Yu CP、Yang T、You SL、Chen CJ、Sun CA，「Androgen receptor gene CAG repeats, estrogen exposure status, and breast cancer susceptibility.」，Euro J Cancer Prev 卷， 期 (2008-08-01) ：317-322 (SCI) Lai HC、Lin YW、Huang THM、Yan P、Huang RL、Wang HC、Liu J Chan MWY、Chu TY、Sun CA、Chang CC Yu MH，「Identification of novel DNA methylation markers in cervical cancer.」，Int J Cancer 卷， 期 (2008-07-01) ：161-167 (SCI) Chen CL、Yang HI、Yang WS、Liu CJ Chen PJ、You SL、Wang LY、Sun CA、Lu SN、Chen DS、Chen CJ，「Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: A follow-up study in Taiwan.」，Gastroenterology 卷， 期 (2008-07-01) ：111-121 (SCI) Huang HP、Hsu HY、Chung TC、Sun CA、Chu CM、Yang T，「An investigation of metabolic syndrome indicators among different ethnic groups: A case study from a health screening in Pingtung area.」，Taiwan J Public Health 卷， 期 (2008-06-01) ：250-258 Yu CP、Yu JC、Sun CA、Tzao C、Ho JY、Yen AM，「Tumor susceptibility and prognosis of breast cancer associated with the G870A polymorphism of CCND1.」，Breast Cancer Res Treat 卷， 期 (2008-01-01) ：95-102 (SCI) Chang YT、Chu CM、Chien WC、Chou YC、Yang T、Lu YF、Pai CY、Pai L Wetter T、Sun CA、Loh CH，「Predicting cervical cancer survivability: A comparison of three data mining methods.」，Taiwan J Fam Med 卷， 期 (2007-10-01) ：222-238 Tian YF、Chu CH、Wu MH、Chang CL、Yang T、Chou YC、Hsu GC、Yu CP、Yu JC、Sun CA，「Anthropometric measures, plasma adiponectin, and breast cancer risk.」，Endocr Relat Cancer 卷， 期 (2007-09-01) ：669-677 (SCI) Yu CP、Wu MH、Chou YC、Yang T、You SL、Chen CJ、Sun CA，「Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: A nested case-control study in Taiwan.」，Anticancer Res 卷， 期 (2007-06-01) ：1727-1732 (SCI) Liou SH、Sun CA、Tung HT、Lai CH、Chung TC、Chou YC、Yang T，「Effects of anticoagulants and duration of storage on blood lead levels. 」，Taiwan J Public Health 卷， 期 (2007-06-01) ：254-260 Naucler P、Chen HC、Persson K、You SL、Hsieh CY、Sun CA、Dillner J、Chen CJ，「Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical Cancer risk: nested case-control study.」，J Gen Virol 卷， 期 (2007-03-01) ：814-822 (SCI) Chou YC、Lee MS、Wu MH、Shih HL、Yang T、Yu CP、Yu JC、Sun CA，「Plasma homocysteine as a metabolic risk factor for breast cancer: findings from a case-control study in Taiwan.」，Breast Cancer Res Treat 卷， 期 (2007-01-01) ：199-205 (SCI) Chou YC、Wu MH、Yu JC、Lee MS、Yang T、Shih HL、Wu TY、Sun CA，「Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: A case-control study in Taiwan.」，Carcinogenesis 卷， 期 (2006-11-01) ：2295-2300 (SCI) Yang T、Sun CA、Hsu HY、Liou SH、Wu DM、Chu SF、Tung HJ、Chen YC、Chen JC，「Stability of blood lead levels in stored specimens: Effects of storage time and temperature.」，J Med Sci 卷， 期 (2006-10-01) ：211-214 He ZM、Lu YF、Hsu CW、Pai CY、Pai L、Chou YC、Sun CA、Wetter T、Lin JD Yang T、Chu CM，「Predicting cervical cancer survivability: A comparison of three data mining methods.」，Taiwan J Fam Med 卷， 期 (2006-09-01) ：192-203 Huang YK、Hsieh HC、Sun CA、Chao CF、Huang RL、Lai HC、Chu TY，「Genetic polymorphisms of phase I and phase II xenobiotic enzymes in human papillomavirus related lesion and cancer of the uterine cervix.」，Tzu Chi Med J 卷， 期 (2006-07-01) ：267-274 Lai HC、Peng MY、Nieh S、Yu CP、Chang CC、Lin YW、Sun CA、Chu TY，「Differential viral loads of human papillomavirus 16 and 58 infections in the spectrum of cervical carcinogenesis.」，Int J Gynecol Cancer 卷， 期 (2006-04-01) ：730-735 (SCI) Wu MH、Chou YC、Yu JC、Yu CP、Wu CC、Chu CM Yang T、Lai CH Hsieh CY、You SL、Chen CJ、Sun CA，「Hormonal and body size factors in relation to breast cancer risk: A prospective study of 11,889 women in a low-incidence area.」，Ann Epidemiol 卷， 期 (2006-03-01) ：223-229 (SCI) Sun CA、Hsiung CA、Lai CH、Chen CA、Chou CY、Ho CM、Twu NF、Feng WL、Chuang MH、Hsieh CY Chu TY，「Epidemiologic correlates of cervical human papilomavirus prevalence in women with abnormal Pap smear tests: A Taiwan Cooperative Oncology Group (TCOG) Study. 」，J Med Virol 卷， 期 (2005-10-01) ：273-281 (SCI) Lin WY、Chou YC、Wu MH、Jeng YL、Huang HB、You SL、Chu TY、Chen CJ、Sun CA，「Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: A nested case-control study in Taiwan.」，Cancer Detect Prev 卷， 期 (2005-07-01) ：427-432 (SCI) Lin SC、Chou YC、Wu MH、Wu CC、Lin WY、Yu CP、Yu JC、Chen CJ、Sun CA，「Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.」，Eur J Cancer Prev 卷， 期 (2005-06-01) ：257-261 (SCI) Luo ST、Chou YC、Wu MH、Yang T、Chu CM、Lai CH、You SL、Chen CJ、Sun CA，「Epidemiological correlates of impaired liver function in Taiwan, an area endemic for chronic liver disease.」，J Med Sci 卷， 期 (2005-04-01) ：71-76 Chou YC、Wu MH、Wu CC、Yang T、Chu CM、Lai CH、Hsieh CY、You SL 、Chen CJ、Sun CA，「Total urinary isothiocyanates, glutathione S-transferase M1 genotypes, and lung cancer risk: A preliminary nested case-control study in Taiwan.」，J Med Sci 卷， 期 (2005-02-01) ：21-26 Lin WY、Chou YC、Wu MH、Huang HB、Jeng YL、Wu CC、Yu CP Yu JC、You SL Chu TY、Chen CJ、Sun CA，「The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: A nested case-control study in Taiwan.」，Anticancer Res 卷， 期 (2004-11-01) ：3863-3868 (SCI) Shen MH、Wu DM、Lee MS、Sun CA、Liou SH、Wang HJ、Wu SB、Chu NF，「To set-up and develop a health data base of military employees in Taiwan.」，Chinese J Occup Med 卷， 期 (2004-04-01) ：95-106 Sun CA、Chen CJ，「Aflatoxin-induced hepatocarcinogenesis: Epidemiological evidence and mechanistic considerations.」，J Med Sci 卷， 期 (2003-12-01) ：311-318 Jeng YL、Wu MH、Huang HB、Lin WY、You SL、Chu TY、Chen CJ、Sun CA，「The methylenetetrahydrofolate reductase 677C➙T polymorphism and lung cancer risk in a Chinese population.」，Anticancer Res 卷， 期 (2003-11-01) ：5149-5152 (SCI) Sun CA、Wu DM、Lin CC、Lu SN、You SL、Wang LY、Wu MH、Chen CJ，「Incidence and co-factors of hepatitis C virus-related hepatocellular carcinoma: A prospective study of 12,008 men in Taiwan.」，Am J Epidemiol 卷， 期 (2003-04-01) ：674-682 (SCI) Wang LY、You SL、Lu SN、Ho HC、Wu MH、Sun CA、Yang HI、Chen CJ，「Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan.」，Cancer Causes Control 卷， 期 (2003-04-01) ：241-250 (SCI)

 

學術會議論文

Chang-Jung Shen、Chien-An Sun、Yu-Ching Chou，「Trends in incidence of colorectal cancer with obstructive sleep apnea in Taiwan」， 51th Annual meeting of The Sociey for Epidemiologic Research， Baltimore, Maryland， USA， Sociey for Epidemiologic Research， 2018-06-19 ~2018-06-22 Chun-Teng Tsai、Chien-An Sun、Yu-Ching Chou，「Increasing incidence of vascular dementia with hormone replacement therapy」， 51th Annual meeting of The Sociey for Epidemiologic Research， Baltimore, Maryland， USA， Society for Epidemiologic Research， 2018-06-19 ~2018-06-22 周雨青、王思穎、何佳容、孫建安，「尿酸濃度變化與高血糖的關係」， 台灣公共衛生學會 台灣流行病學學會 台灣事故傷害預防與安全促進學會 台灣癌症登計學會 2016年聯和年會， 台北市， 中華民國， 台灣公共衛生學會， 2016-10-15 ~2016-10-16 林士傑、周與青、游山林、梁鈞瑜、孫建安，「台灣地區睡眠品質 睡眠時數與代謝症候群之關聯性探討」， 台灣公共衛生學會 台灣流行病學學會 台灣事故傷害預防與安全促進學會 台灣癌症登計學會 2015年聯和年會， 台北市， 中華民國， 台官公共衛生學會， 2015-10-17 ~2015-10-18 詹芳絮、孫建安，「睡眠品質與代謝症候群相關性探討」， 台灣公共衛生學會 台灣流行病學學會 台灣事故傷害預防與安全促進學會 台灣癌症登計學會 2015年聯和年會， 台北市， 中華民國， 台灣公共衛生學會， 2015-10-17 ~2015-10-18 林士傑、孫建安、周雨青、梁鈞瑜、趙威、甘博介、關仁俊、黃仁明，「Prevalence and health service utilization of sleep disorder patients in Taiwan-Using panel claims data of National Health Insurance Beneficiaries」， 第41屆國軍軍醫學術研討會， 台北市， 中華民國， 國防醫學院， 2014-11-24 ~2014-11-24 孫建安，「The association between sleep disorders and dementia:A hospital-based case-control study」， 2014 台灣睡眠醫學會研討會， 新北市， 中華民國， 台灣睡眠醫學會， 2014-03-29 ~2014-03-30 孫建安，「Status of associated factors for the subjective sleep problems in obesity adults : An epidemiological assessment」， 7th General assembly and International Conference of Asia Pacific Organization for Cancer Prevention， Taipei City， Taiwan, Republic of China， Asia Pacific Organization for Cancer Prevention， 2014-03-20 ~2014-03-23 Wu MH、Chou YC、Yu CP、Yu JC、Lee MS、Sun CA，「Germ-line polymorphisms in the MTHFR gene, diet, and breast cancer susceptibility: A case-control study in Taiwan.」， Annual Meeting of the Graduate Institute of Life Sciences, National Defense Medical Center, 2007， Longtan， Taiwan， National Defense Medical Center， 2007-04-21 Chou YC、Wu MH、Yu JC、Yu CP、Chu CM、Sun CA，「Plasma homocysteine as a risk factor for breast cancer: A case-control study in Taiwan.」， Annual Meeting of Taiwan Public Health Association, Taipei, Taiwan, 2006.， Taipei， Taiwan， Taiwan Public Health Association， 2006-09-30 Sun CA，「The role of HPV in cervical neoplasia.」， Taiwan cervical cancer prevention summit, Taipei, Taiwan, 2006.， Taipei， Taiwan， 2006-09-23 Jan CF、You SL、Sun CA、Chen TI、Yang HI、Lu SN、Chen SC、Chen HH、Chen CJ，「A community-based randomized trial on hepatocellular carcinoma screening using abdominal ultrasonography and alpha-fetoprotein in Taiwan.」， 41st Annual Meeting of the European Association for the Study of the Liver， Vienna， Austria， 2006-04-26 Huang YT、Yang HI、Jen CL、Iloeje UH、Su J、You SL、Wang LY、Sun CA、Chen CJ，「Suppression of hepatitis B virus replication by hepatitis C virus: Combined effects on risk of hepatocellular carcinoma.」， 56th Annual Meeting of the American Association for the Study of Liver Diseases， San Francisco， United States of America， American Association for the Study of Liver Diseases， 2005-11-11 Sun CA，「Epidemiologic correlates of cervical HPV infections in Taiwan.」， International Symposium on HPV in Taiwan, Taipei, Taiwan, 2005.， Taipei， Taiwan， 2005-07-10 Sun CA，「Folate, hormones, and breast cancer risk in Taiwan.」， International Symposium on Nutrition, Diet and Cancer, Taipei, Taiwan, 2005.， Taipei， Taiwan， 2005-05-20 Chen TI、Sun CA、You SL、Chen HH、Hsieh CY、Chen CJ，「Evaluation of liver cancer screening effectiveness in a high-risk population: Preliminary results of a randomized community trial.」， 14th Annual Meeting of Taiwan Public Health Association, Taipei, Taiwan, 2004.， Taipei， Taiwan， Taiwan Public Health Association， 2004-10-23 Lin YH、You SL、Sun CA、Hsieh CY，「A prospective study of nasopharyngeal carcinoma in a high-risk population.」， 14th Annual Meeting of Taiwan Public Health Association, Taipei, Taiwan, 2004.， Taipei， Taiwan， Taiwan Public Health Association， 2004-10-23 Hsieh HC、Sun CA、Lai HC、Chao CF、Chu TY，「Human papillomavirus infection and genetic polymorphisms of xenobiotic enzymes are associated with risk of cervical cancer development.」， 2nd NHRI Conference on Cancer Genomics, Aspire Learning Complex, Tao-Yuan, Taiwan, 2002.， Tao-Yuan， Taiwan， National Health Research Institutes， 2002-08-16 Chu TY、Hsieh HC、Sun CA、Lai HC、Chao TF，「Polymorphism of CYP 1A1 and GSTM1 and risk of cervical cancer development.」， 93th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, 2002.， San Francisco， United States of America， 2002-04-06 Chu TY、Hsu JH、Huang RL、Chen JY、Sun CA、Hsieh CY，「Quantitative measurement of human papillomavirus load in cervical swabs by using Hybrid Capture II assay.」， 5th International Conference of the Asian Clinical Oncology Society, Taipei, Taiwan, 2001.， 臺灣， Formosa Cancer Foundation ， 2001-04-05 Sun CA、Chu TY，「Human papillomavirus infection and cervical neoplasia in Taiwan: Epidemiological considerations.」， Workshop on quality assurance of Pap smear and colposcopic examination， Taipei， Taiwan， Association of Obstetrics and Gynecology， 2001-03-31 Hsieh HC、Sun CA、Tsao CF、Chu TY，「Metabolizing cancer-susceptibility gene polymorphism in cervical cancer.」， Annual Meeting of the Taiwan Association of Obstetrics and Gynecology, Taipei, Taiwan, 2001.， Taipei， Taiwan， Taiwan Association of Obstetrics and Gynecology， 2001-03-31 Hsieh HC、Sun CA、Tsao CF、Chu TY，「Metabolizing cancer-susceptibility gene polymorphism in cervical cancer.」， Annual Meeting of the Taiwan Association of Obstetrics and Gynecology, Taipei, 2001， Taipei， Taiwan， Taiwan Association of Obstetrics and Gynecology， 2001-03-31 Sun CA、Wu DM、Pai L、Chu NF、Lee MS、Tsai JT、Hsu LL、Lee MC、Sung PK，「Prevalence and correlates of elevated C-reactive protein levels: The MJ Health Screening Center Study.」， Biennial Conference of the International Health Evaluation Association, Taipei, Taiwan, 2000.， Taipei， Taiwan， 2000-06-10 Pai L、Wu DM、Sun CA、Chu NF、Lee MS、Tsai JT、Hsu LL、Lee MC、Sung PK，「Prevalence of cardiovascular disease risk factors among adults: Results from a Health check-up population screening in Taiwan.」， Biennial Conference of the International Health Evaluation Association, Taipei, Taiwan, 2000.， Taipei， Taiwan， International Health Evaluation Association， 2000-06-10 Wu DM、Pai L、Sun CA、Tsai JT、Hsu LL、Lee MC、Sung PK，「A preliminary study on the individual aggregation in cigarette smoking, alcohol drinking, and betel-nut chewing in a health check-up population.」， Biennial Conference of the International Health Evaluation Association, Taipei, Taiwan, 2000.， Taipei， Taiwan， International Health Evaluation Association， 2000-06-10 Lee MS、Wu DM、Chu NF、Sun CA、Pai L、Hong Y、Tsai JT、Hsu LL、Sung PK，「Familial aggregation of serum cholesterol and triglyceride levels: Results from a health check-up population in Taiwan.」， Biennial Conference of the International Health Evaluation Association, Taipei, Taiwan, 2000.， Taipei， Taiwan， International Health Evaluation Association， 2000-06-10 Chu TY、Sun CA、Lai HC、Yu MH，「The significance of HPV viral load in prediction of lesion size and severity of squamous intraepithelial lesions and cervical cancer.」， 4th International Multidisciplinary Congress on Global Challenge of Cervical Cancer Prevention， Paris， France， 2000-05-12 Chu TY、Lai HC、Sun CA、Yu MH，「Favorable clinical outcome of cervical cancers infected with human papillomavirus type 58 and related types.」， 4th International Multidisciplinary Congress on Global Challenge of Cervical Cancer Prevention， Paris， France， 2000-05-12 Chu TY、Sun CA、Chen CY、Chen HJ、Yu MH，「Plasma HPV viral load as an indicator of HSIL and invasive cancer of uterine cervix.」， 4th International Multidisciplinary Congress on Global Challenge of Cervical Cancer Prevention， Paris， France， 2000-05-12 Sun CA、Wang LY、You SL、Chen CJ、Santella RM，「Glutathion S-transferase M1 and T1 genetic polymorphisms as a modulator of aflatoxin-associated hepatocarcinogenesis in Taiwan.」， 91th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, 2000.， San Francisco， United States of America， American Association for Cancer Research， 2000-04-14 Liu JF、Chu TY、Sun CA，「Plasma micronutrient levels and the risk of cervical precancerous lesions: A case-control study.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1999.， Taipei， Taiwan， Taiwan Public Health Association， 1999-10-23 Wu KB、Chang SC、Sun CA，「Plasma retinol levels and the risk of liver cirrhosis: A nested case-control study.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1999.， Taipei， Taiwan， Taiwan Public Health Association， 1999-10-23 Sun CA、Yu MH、Chen HJ、Lai HC、Liu JY、Chu TY，「The significance of HPV viral load in prediction of lesion size and severity of squamous intraepithelial lesions and cervical cancer.」， Conference on Human Papillomavirus Infection and Cervical Cancer: Basic and Clinic, Taipei, 1999.， Taipei， Taiwan， 1999-09-18 Sun CA、Yang HI、Lu MC、You SL、Chen CJ，「Risk factors in development of liver cancer: comparative analysis of hepatitis B virus carriers and noncarriers.」， Annual Meeting of the American Association for Cancer Research, Philadelphia, PA, 1999.， Philadelphia， United States of America， American Association for Cancer Research， 1999-04-16 Hsu WL、Sun CA、Lu MC、Yang HI、Su S、Chen CJ，「Risk factors for impaired liver function in male adults in Taiwan area.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association ， 1998-10-17 Hsu WL、Lee JM、Sun CA、Chen CJ，「Esophageal cancer in Taiwan: Incidence, mortality, and survival rates.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association， 1998-10-17 Hsu YH、Sun CA，「Epidemiology of Chlamydia trachomatis infection in women in Taipei area.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association， 1998-10-17 Shiu YM、Sun CA、Wu MH、Hsu YH、Liu JY、Shao MF，「Epidemiology of Trichomonas vaginalis infection in Taiwanese women: A hospital-based cross-sectional study.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association， 1998-10-17 Yang SC、Sun CA、Hsieh CY、Chen CJ，「Associations of infection with Mycoplasmas genitalium, and Mycoplasmas hominis with squamous intraepithelial lesions of the cervix: A population-based case-control study.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association， 1998-10-17 Lai CW、Sun CA、Hsieh CY、Chen CJ，「Chlamydia trachomatis , herpes simplex virus and human papillomavirus for high-grade squamous intraepithelial lesions of the cervix: A population-based case-control study.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association， 1998-10-17 Jen CL、Sun CA、Hsieh CY、Chen CJ，「Human papillomavirus infection and squamous intraepithelial lesions of the cervix: A population-based case-control study.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1998.， Taipei， Taiwan， Taiwan Public Health Association， 1998-10-17 Sun CA、Wu DM、Pai L、Hsu LL、Tsai JT、Lee MC、Sung PK，「Dyslipoproteinemias in mass screening of Chinese population: The MJ Health Screening Center Study.」， International Health Evaluation Association Conference, London, 1998.， London， United Kingdom， International Health Evaluation Association， 1998-04-24 Pai L、Wu DM、Sun CA、Hsu LL、Tsai JT、Sung PK，「Clustering phenomena of behavioral risk factors among general adults in Taiwan.」， International Health Evaluation Association Conference, London, 1998.， London， United Kingdom， International Health Evaluation Association ， 1998-04-24 Wu DM、Sun CA、Pai L、Hsu LL、Tsai JT、Lee MC、Sung PK，「The predictive factors for blood pressure values among healthy Taiwanese adults.」， International Health Evaluation Association Conference, London, 1998.， London， United Kingdom， International Health Evaluation Association ， 1998-04-24 Sun CA、You SL、Lu SN、Wu MH、Chen CJ，「Persistence of the etiologic effect of hepatitis C and hepatitis B virus infection on risk of liver cirrhosis.」， Annual Meeting of the American Association for Cancer Research, New Orleans, LA, 1998.， New Orleans， United States of America， American Association for Cancer Research， 1998-04-17 Yang HI、Sun CA、Chen CJ，「Prevalences of hypertension, hyperlipidemia, cigarette smoking, and alcohol drinking in Taiwan: A seven-township study.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1997.， Taopei， Taiwan， Taiwan Public Health Association ， 1997-10-11 Wu MH、Sun CA、Chen CJ，「Incidence and multiple risk factors of hepatocellular carcinoma among patients with liver cirrhosis.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1997.， Taipei， Taiwan， Taiwan Public Health Association， 1997-10-11 Lu MC、Sun CA、Huang WT、Hsien CY、Chen CJ，「Human papillomavirus and squamous intraepithelial lesions of the cervix: A longitudinal study in Taiwan.」， Annual Meeting of the Public Health Association (ROC), Taipei, Taiwan, 1997.， Taipei， Taiwan， Taiwan Public Health Association， 1997-10-11 Hsu WL、Sun CA、Chen CJ，「Prevalence of hyperuricemia in Taiwan area: A seven-township study.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1997.， Taipei， Taiwan， Taiwan Public Health Association ， 1997-10-11 Sun CA、Farzadegan H、Wolfe L、Hardy W、You SL、Lu SN、Wu MH、Chen CJ，「Quantitation of serum hepatitis C virus RNA in Chinese patients with hepatocellular carcinoma: A population-based case-control study in Taiwan.」， Annual Meeting of the American Association for the Study of Liver Diseases, Chicago, IL, 1994.， Chicago， United States of America， American Association for the Study of Liver Diseases， 1994-10-28 Sun CA、Chang AS、You SL、Pan WH、Chen CJ、Liu WT，「Epidemiological investigation on immunization of measles, rubella, and poliomyelitis among preschool and school children in Taiwan.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1990.， Taipei， Taiwan， Taiwan Public Health Association ， 1990-10-13 You SL、Pan WH、Chen CJ、Liu WT 、Lan CF、Chang AS、Sun CA、Wang WC、Wu CW，「A community-based longitudinal study of risk factors associated with body fluid transmitted virus infections and cardiovascular diseases in Taiwan.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1990.， Taipei， Taiwan， Taiwan Public Health Association ， 1990-10-13 Liu WT、Chen CJ、Wang WC、Sun CA、Wu CW，「Seroepidemiology of Epstein-Barr virus among children in Taiwan.」， Ⅷth International Congress of Virology, Berlin, 1990， Berlin， Germany， International Congress of Virology， 1990-08-10 Wang WC、Liu WT、Chen CJ、Sun CA、You SL、Wu CW，「Seroepidemiology of human T-cell lymphotropic virus type I (HTLV-I) infection in Chutung and Potzu Townships in Taiwan.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1989.， Taipei， Taiwan， Taiwan Public Health Association ， 1989-10-07 Hsieh SF、Wang WC、You SL、Sun CA、Chang AS、Pan WH、Liu WT、Chen CJ、Wu CW，「Seroepidemiology of hepatitis A virus infection among children in Taiwan.」， Annual Meeting of the National Public Health Association (ROC), Taipei, Taiwan, 1989.， Taipei， Taiwan， Taiwan Public Health Association ， 1989-10-07

 

科技部研究計畫

孫建安、周雨青 陳建華，「晝夜節律變異與代謝症候群之相關性：日韻律型態與晝夜節律相關基因多形性之探討」， 2017-08-01~2018-07-31 ，106-2314-B-030-006- 孫建安、陳建華 周雨青 楊崑德，「睡眠障礙、生理節律失能與代謝症候群之相關性」， 2016-08-01~2017-07-31 ，104-2314-B-030-004-MY2 孫建安、陳建華 周雨青 楊崑德，「睡眠障礙、生理節律失能與代謝症候群之相關性（二年期）」， 2015-08-01~2017-07-31 ，MOST104-2314-B-030-004-MY2 孫建安、楊燦、周雨青、吳美萱、俞志誠、侯藹玲，「發炎反應和免疫反應之個體易感受性及服用非類固醇抗發炎反應藥物與罹患婦女乳癌風險相關性之流行病學研究」， 2012-08-01~2015-07-31 ，NSC101-2314-B-030-008-MY3 周雨青、孫建安、楊燦、吳昌杰，「國人大腸直腸癌DNA甲基化生物標記的確認及應用」， 2012-08-01~2013-07-31 ，NSC 101-2314-B-016-029 孫建安、楊燦、周雨青，「發炎反應與罹患乳癌危險性之流行病學研究」， 2011-08-01~2012-07-31 ，NSC 100-2314-B-030-002 周雨青、孫建安、楊燦、吳昌杰，「國人大腸直腸癌DNA甲基化生物標記的確認及應用」， 2011-08-01~2012-07-31 ，NSC 100-2314-B-016-025 周雨青、吳昌杰、孫建安，「國人大腸直腸癌DNA甲基化生物標記的確認及應用」， 2010-08-01~2011-07-31 ，NSC 99-2314-B-016-020 周雨青、孫建安、吳昌杰，「利用糞便中外遺傳標記篩檢大腸直腸癌之研究」， 2009-01-01~2009-07-31 ，NSC 98-2314-B-016-001 孫建安，「肥胖與乳癌：脂肪細胞生成與發炎反應因子所扮演的角色」， 2008-08-01~2011-07-31 ，NSC97-2314-B-030-006-MY3, NSC97-2314-B-030-006-MY3 孫建安，「肥胖與乳癌：脂肪細胞激素與類胰島素生長因子所扮演的角色」， 2006-08-01~2009-07-31 ，NSC95-2314-B-016-044-MY3, NSC 95-2314-B-030-004-MY 孫建安，「子宮頸癌非侵襲性分子診斷與資訊系統之開發」， 2005-12-01~2007-11-30 ，NSC94-2622-B-016-001, NSC 95-2622-B-016-001 孫建安，「甲基組群代謝基因之基因多形性與罹患乳癌易感受性之分子流行病學研究」， 2005-08-01~2006-07-31 ，NSC94-2314-B-016-014 孫建安，「甲基組群代謝基因之基因多形性與罹患乳癌易感受性之分子流行病學研究」， 2004-08-01~2005-07-31 ，NSC93-2320-B-016-016 孫建安，「飲食與個體易感受性在罹患肺癌危險性之交互作用」， 2002-08-01~2004-07-31 ，NSC91-2320-B-016-035, NSC92-2320-B-016-043 孫建安，「血中抗氧化微量營養素濃度與代謝酵素基因多形性在罹患與抽菸相關癌症之個體易感受性的探討」， 2000-08-01~2002-07-31 ，NSC89-2314-B-016-120, NSC90-2320-B-016-041 孫建安，「人類疣瘤病毒16型病毒鞘膜抗體之血清學研究」， 1999-08-01~2000-07-31 ，NSC89-2320-B-016-051 孫建安，「C型肝炎病毒感染之死亡率分析」， 1998-08-01~1999-07-31 ，NSC88-2314-B-016-024 孫建安，「婦女感染陰道滴蟲之流行病學研究」， 1997-08-01~1998-07-31 ，NSC87-2314-B-016-093

 

非科技部研究計畫

孫建安，「長期呼吸器依賴病患有無合併呼吸器相關肺炎的住院醫療總費用及醫療照護品質結果之分析」， 國泰醫療財團法人國泰綜合醫院， 2018-08-01~2019-07-31 孫建安，「史他汀(Statin)類藥物的使用與罹患腎臟癌之風險」， 國泰醫療財團法人國泰綜合醫院， 2017-08-01~2018-07-31 孫建安，「結直腸癌診療照護型態及醫院間照護變異研究」， 奇美醫療財團法人奇美醫院， 2016-10-01~2017-09-30 陳鵬文、孫建安，「成人預測保健服務B, C型肝炎篩檢查詢系統建置及篩檢資料分析計畫」， 衛生署國民健康局， 2012-05-17~2012-12-15 孫建安，「國人葉酸之營養狀況與罹患癌症風險之探討」， 2007-03-01~2009-02-28 孫建安，「2007年台灣地區高血壓、高血糖、高血酯之追蹤調查研究」， 2006-11-14~2008-12-31 孫建安，「葉酸與女性乳癌之病例對照研究」， 2004-01-01~2005-12-31 孫建安，「台灣地區女性乳癌之營養流行病學研究」， 2003-01-01~2003-12-31 孫建安，「以尿液檢體篩檢國內婦女感染披衣菌可行性之研究」， 1999-07-01~2000-06-30 孫建安，「血清維生素A濃度之流行病學研究」， 1998-07-01~1999-06-30 孫建安，「性接觸傳染砂眼披衣菌之流行病學研究」， 1997-07-01~1998-06-30

 

獲獎紀錄

孫建安，「103學年度教學績優教師」， 輔仁大學， 103 孫建安，「技術轉移貢獻獎」， 國防醫學院， 98 孫建安，「大智獎章」， 中華民國私立教育事業協會， 98 孫建安，「國防醫學院公共衛生學系特殊成就與貢獻獎」， 國防醫學院， 95 孫建安，「國防部優良教師」， 國防部， 95 孫建安，「國防部優良教師」， 國防部， 91 孫建安，「國防醫學院傑出校友」， 國防醫學院， 91 孫建安，「國家科學委員會研究獎勵」， 國家科學委員會， 89 孫建安，「國家科學委員會研究獎勵」， 國家科學委員會， 85

 

我所主持的研究室主要是以流行病學的研究方法，在台灣社區設立大型的研究世代(cohort)作為研究對象的來源，來探討台灣地區常見癌症以及代謝性疾病的危險因子。藉由長期追蹤社區居民的研究成果，提供研擬癌症與代謝性疾病防治政策的參考。另一方面，隨著分子流行病學方法的演進和人類基因體研究的進展，我利用在社區設立之大型研究世代，經過長期追蹤後，以重疊病例對照(nested case-control)的研究方法，並以基礎收案時所取得之生物檢體，來進行代表個體易感受性之基因多形性(諸如：參與致癌物代謝、抗氧化反應、葉酸代謝、賀爾蒙代謝之基因)與罹患癌症風險的關聯性。近年來，我以隨機取樣的方式於台灣全島取得樣本，以問卷收集資料也收集血液檢體來分析台灣地區成年人(20歲以上)高血壓、高血糖、高血脂之盛行率與發生率以及危害因素。自2016年起迄今，我帶領台灣的研究團隊參與美國Stanford University所發起的幸福感(wellness)研究。此一研究在美國Bay area(由Stanford University負責)、中國杭州(由浙江大學負責)、台灣新北市(由我現在任教之輔仁大學負責）以及新加坡(由新加坡國立大學負責)建立社區的研究世代，來評估一般人民的幸福感狀態以及探測影響幸福感的生物標記。此一跨國研究是一同時兼顧從群體角度(中西文化差異)以及個人角度(人民的感受)來建立幸福感的測量理論與方法、探討中西文化差異之幸福感差異(比較中國杭州和台灣新北市與美國灣區居民幸福感的差異，而新加坡則介於中西文化差異之間)、評估一般人民的幸福感狀態以及探測影響幸福感的生物標記。這也是我目前的研究重心。

具體而言，我在台灣地區七個鄉鎮市建立台灣人民常見癌症的篩檢世代。此一研究世代於1990年7月至1992年6月間在澎湖地區之馬公(Makung)、湖西(Huhsi)、白沙(Paihsa)以及台灣本島之三芝(Sanchi)、竹東(Chutung)、朴子(Postzu)、高樹(Kaohsu)等地(圖一)所建立。

圖一. 台灣地區七個鄉鎮市所建立之癌症篩檢世代

我以此一台灣地區七個鄉鎮市的追蹤世代為研究基礎，陸續於國際學術期刊發表研究成果。若干研究成果摘述如下：

於1991-1992期間，11893名男性民眾經過92359人年的追蹤，發生111名肝細胞癌病例。經血液檢體檢測發現，B型肝炎病毒感染標記:HBsAg和HBeAg同時陽性者相較於兩個標記同時陰性者，罹患肝細胞癌的相對危險性是60.2(95% 信賴區間:35.5-102.1)。此一研究成果彰顯B型肝炎病毒感染標記HBeAg預測癌症風險的重要性，刊登於國際頂尖期刊New England Journal of Medicine (2002;347:168-174)。

 

於1990-1991期間，11889名女性民眾經過134063人年的追蹤，共發現104名新發生乳癌病例，發生率為每十萬人年77.6(95% CI=63.7-94.3/100,000人年)。我們界定女性初經年齡至生育第一胎年齡之時間間隔為乳房細胞暴露於動情激素之重要時期，並將此一時期以三分位分組，發現此一時期在10年(含)以上之婦女的乳癌累積發生率(1.65%)顯著高於此一時期在7-9年之間的婦女(累積發生率:0.77%)及此一時期在6年(含)以下之婦女(累積發生率:0.45%)(如圖三所示)。此一研究結果顯示，台灣地區雖然在國際間是婦女乳癌低發生率地區，但是乳癌的病因學亦如歐美國家高發生率地區一樣，是以賀爾蒙暴露為主要的危險因子。此一研究成果刊登於”Annals of Epidemiology”( 2006;16:223-229,我為責任作者)。

圖三. 不同女性賀爾蒙暴露期間與女性乳癌危險性之關聯性

 

我及研究室同僚繼續以上述之癌症篩檢追蹤世代為基礎，並以重疊病例對照的研究設計，來探討參與女性賀爾蒙代謝之基因的單核苷酸變異(single nucleotide polymorphism, SNP)與罹患乳癌危險性之關聯性。於1992-2000期間所產生之88位乳癌病例與344位配對之健康對照，針對葉酸代謝之重要酵素：甲烯基四氫葉酸還原酶（methylenetetrahydrofolate reductase, MTHFR）之基因多形性及女性賀爾蒙暴露年數與乳癌生成之關聯性進行重疊病例對照研究。研究結果發現，長期暴露於女性賀爾蒙之婦女，若其MTHFR也產生單核苷酸變異，則會顯著提高其罹患乳癌的危險性此一研究結果發表於Anticancer Research（2004;24:3863-3868,我為責任作者）。另於1992-2001年所產生之99位乳癌病例及366位配對之健康對照，針對抗氧化酵素，myeloperoxidase(MPO)，及參與女性賀爾蒙代謝之酵素，COMT的基因多形性進行重疊病例對照研究。研究結果發現婦女若長期暴露於女性賀爾蒙(以初經年齡與生育第一胎年齡之間隔年數來代表)，而且參與女性賀爾蒙代謝之基因產生突變，則會提高其罹患乳癌的危險性。此一研究結果刊登於European Journal of Cancer Prevention（2005;14:257–261,我為責任作者）。在1991-2001期間所產生之109名原發性乳癌病例與421名配對之健康社區對照，針對絲氨酸羥甲基轉移酵素(SHMT1)、甲硫胺酸合成酵素(MS)和MTHFR於葉酸代謝過程扮演重要酵素之基因多形性及彼此間基因-基因交互作用在乳癌生成的癌化過程中所扮演的角色。研究結果發現至少帶有一個危險基因型且長期暴露於女性賀爾蒙的婦女，則會顯著提高罹患乳癌的危險性 。此一研究成果刊登於Anticancer Research(2007;27:1727-1732,我為責任作者)。

我於2007年以多階段隨機取樣的方法取得之台灣的區全島的代表性樣本共3857位民眾，延續2002年執行之「台灣地區高血壓、高血糖、高血脂盛行率調查」的研究計畫，追蹤此一3857位民眾發現血中尿酸濃度是罹患代謝症候群的重要危險指標。隨著血中尿酸濃度的增加，罹患代謝症候群的風險也隨之提高。此一“劑量效應關係”(dose-response relationship)在女性比在男性明顯。此一研究成果發表於國際優良學術期刊Atherosclerosis (2012;220:525-531)。我所負責執行此一具有台灣地區全島代表性樣本之社區型研究，後來參與國際慢性病危害因素研究聯盟(NCD Risk Factor Collaboration, NCD-RisC)，陸續發表研究成果於國際頂尖學術期刊。國際慢性病危害因素研究聯盟使用來自於200個地理區域1698個以族群為基礎的研究世代(包含本具有台灣地區全島代表性樣本之社區型研究世代)所收集的資料，分析發現年齡別校正之肥胖盛行率從1975年之3.2%上升至2014年之10.8%(男性)，從1975年之6.4%%上升至2014年之14.9%(女性)。然而，體重不足(underweight)仍然是經濟條件不佳之地理區域(特別是南亞地區)盛行的問題。此一研究成果發表於國際頂尖學術期刊Lancet (2016;387:1377-1396)。

 

圖四、2014年全球年齡校正肥胖盛行率分佈，依性別與地理區域呈現

 

國際慢性病危害因素研究聯盟使用來自751個以族群為基礎的研究世代(包含本具有台灣地區全島代表性樣本之社區型研究世代)所收集的資料，分析發現全球年齡別校正糖尿病盛行率從1980年之4.3%上升至2014年之9.0% (男性)，從1980年之5.0%上升至2014年之7.9% (女性)。造成全球糖尿病盛行率上升的不利因